Update on Lynch syndrome genomics

Update on Genomics Functional Genomics in Plants

The sequencing of the first genome of a higher plant, Arabidopsis, is progressing at a rapid pace. As we are writing these words, almost one-third of the estimated 100 Mb is available in public databases, and with appropriate funding the complete genome sequence is predicted to be finished by the year 2001. Sequencing programs for other plant genomes such as rice are planned, and with new gener...

Genomics update Wine Genomics

Diagnosing Lynch syndrome

R isk stratification is essential for designing efficacious and cost effective colon cancer screening programmes. One of the most important risk factors for colorectal cancers (CRC) is an inherited predisposition, implicated in 20% of all cases. The spectrum of genetic susceptibility ranges from the low penetrance mutations that modestly increase the colon cancer risk (for example, I 1307K) to ...

Lynch syndrome (HNPCC)

Lynch syndrome, also referred to as hereditary non-polyposis colorectal cancer (HNPCC), accounts for somewhere between 2 and 5% of all CRC. It has been shown that Lynch syndrome (LS) is a result of germline mutations in genes involved in DNA mismatch repair (MMR) MSH2, MLH1, MSH6, and PMS2, whereas as HNPCC refers to families that adhere to the Amsterdam criteria or iterations of it. More recen...

Genomics update Genomics of plant-associated microbes